THE USE OF INTERIM DATA AND DATA MONITORING COMMITTEE RECOMMENDATIONS IN RANDOMIZED CONTROLLED TRIAL REPORTS: FREQUENCY, IMPLICATIONS AND POTENTIAL SOURCES OF BIAS

Abstract Background Interim analysis of accumulating trial data is important to protect participant safety during randomized controlled trials (RCTs).Data Monitoring Committees (DMCs) often undertake such analyses, but their widening role may lead to extended use of interim analysis or recommendations that could potentially bias trial results.Metho

BackgroundIn 2015, approximately 42,000 women died as a result of hypertensive disorders of pregnancy worldwide; over 99% of these deaths occurred in low- and middle-income countries.The aim of this paper is to describe the incidence and characteristics of eclampsia and related complications from hypertensive disorders of pregnancy across 10 low- a

We present a system that utilizes a range of image processing algorithms to allow fully automated thermal face analysis under both laboratory and real-world conditions.We implement methods for face detection, facial landmark detection, face frontalization and analysis, combining all of these into a fully automated workflow.The system is fully modul

Global bacterial infections are on the rise, and drug resistance to bacteria is gradually rendering existing antibiotics ineffective.Therefore, the Sweatshirts discovery of new strategies is urgently needed.Cellular metabolism is a key factor in the regulation of bacterial drug resistance, which cannot be separated from the utilization of energetic

Introduction: acute appendicitis constitutes the most frequent emergency in General Surgery Service.When patients are early operated on better prognosis is obtained.Objective: to characterize clinically and epidemiologically the appendectomized patients at Abel Santamaria Cuadrado general teaching hospital.Method: a descriptive, longitudinal Cleans